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Details

Stereochemistry ACHIRAL
Molecular Formula C11H9I3N2O4
Molecular Weight 607.914
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOTHALAMIC ACID I-125

SMILES

CNC(=O)C1=C([125I])C(NC(C)=O)=C([125I])C(C(O)=O)=C1[125I]

InChI

InChIKey=UXIGWFXRQKWHHA-DQKAYFEISA-N
InChI=1S/C11H9I3N2O4/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20/h1-2H3,(H,15,18)(H,16,17)(H,19,20)/i12-2,13-2,14-2

HIDE SMILES / InChI
Iothalamic acid is a Radiographic Contrast Agent. The mechanism of action of iothalamic acid is as a X-Ray Contrast Activity. GLOFIL-125 (Sodium Iothalamate I-125 Injection) is a sterile, nonpyrogenic aqueous injection containing approximately 1 mg sodium iothalamate per mL, and 0.9 percent benzyl alcohol as a preservative. The radioactive concentration of the material is 250-300 µCi/mL as of the calibration date. Sodium bicarbonate and hydrochloric acid are present for pH adjustment. GLOFIL-125 (Sodium Iothalamate I-125 Injection) is indicated for evaluation of glomerular filtration in the diagnosis or monitoring of patients with renal disease. The renal clearance of sodium iothalamate in man closely approximates that of inulin. The compound is cleared by glomerular filtration without tubular secretion or reabsorption. Following infusion administration of I-125 iothalamate, the effective half-life is about 0.07 days.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
GLOFIL-125

Approved Use

Unknown

Sample Use Guides

In the average patient (70 kg) is as follows: Continuous intravenous infusion: 20 to 100 μCi (0.74-3.7 megabecquerels) Single intravenous injection: 10 to 30 µCi (0.37-1.11 megabecquerels)
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Name Type Language
IOTHALAMIC ACID I-125
Common Name English
IOTHALAMIC ACID I 125
Common Name English
IOTHALAMIC ACID, I-125
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1446
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
NDF-RT N0000177914
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
WHO-ATC V09CX03
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
NDF-RT N0000000205
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID50873963
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
PRIMARY
CAS
97914-42-6
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
PRIMARY
PUBCHEM
23724932
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
PRIMARY
RXCUI
1546452
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
PRIMARY RxNorm
DAILYMED
2XLB86RCW8
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
PRIMARY
CAS
59277-60-0
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
ALTERNATIVE
FDA UNII
2XLB86RCW8
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
PRIMARY
NCI_THESAURUS
C87198
Created by admin on Fri Dec 15 16:16:50 GMT 2023 , Edited by admin on Fri Dec 15 16:16:50 GMT 2023
PRIMARY